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CH5132799
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CH5132799图片
CAS NO:1007207-67-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CH-5132799
产品介绍

生物活性

CH5132799是一种新型的I类PI3K抑制剂,尤其对PI3Kα (IC (50) = 0.014μM) 表现出很强的抑制活性。

Targets

TargetValue
PI3KαIC50: 14nM
PI3KγIC50: 36nM
PI3KβIC50: 0.12μM
PI3KδIC50: 0.50μM
mTORIC50: 1.6μM
C2βIC50: 5.3μM
C2αIC50: >10μM
Vps34IC50: >10μM

化学数据

目录号A11169
作用机制Inhibitor (抑制剂)
M. Wt377.42
FormulaC15H19N7O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1007207-67-1
SynonymsCH-5132799
SMILESCS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N

溶解度

In vitro (25°C)DMSO12 mg/mL (31.79 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% DMSO+30% polyethylene glycol+1% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM26.5 mL132.48 mL264.96 mL
0.5 mM5.3 mL26.5 mL52.99 mL
1 mM2.65 mL13.25 mL26.5 mL
5 mM0.53 mL2.65 mL5.3 mL

*The above data is based on the productmolecular weight 377.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.