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GSK1070916
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK1070916图片
CAS NO:942918-07-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
GSK-1070916
产品介绍

生物活性

GSK1070916是一种有效的Aurora B/C激酶抑制剂(IC50为3.5 nM/6.5 nM),在组织培养细胞和人肿瘤异种移植模型中具有广泛的抗肿瘤活性。

Targets

TargetValue
AuroraB-INCENPIC50: 3.5nM
AuroraC-INCENPIC50: 6.5nM
FLT1IC50: 42nM
Tie-2IC50: 59nM
SIKIC50: 70nM
FLT4IC50: 74nM
FGFR1IC50: 76nM
AuroraA-TPX2IC50: 1.1μM

化学数据

目录号A11168
作用机制Inhibitor (抑制剂)
M. Wt507.63
FormulaC30H33N7O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.942918-07-2
SynonymsGSK-1070916
SMILESCCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C

溶解度

In vitro (25°C)DMSO91 mg/mL (179.26 mM)
WaterInsoluble
Ethanol8 mg/mL (15.75 mM)
In vivo2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.7 mL98.5 mL196.99 mL
0.5 mM3.94 mL19.7 mL39.4 mL
1 mM1.97 mL9.85 mL19.7 mL
5 mM0.39 mL1.97 mL3.94 mL

*The above data is based on the productmolecular weight 507.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.