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Wortmannin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Wortmannin图片
CAS NO:19545-26-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
SL-2052
产品介绍

生物活性

Wortmannin是一种有效的,选择性的,可透过细胞的且不可逆的磷脂酰肌醇3-激酶(PI 3-激酶)(IC50 = 2-4 nM)抑制剂,它也有效抑制polo-like激酶1(PLK1)(IC50 = 5.8 nM)。

靶点信息

PI3K (Cell-free assay)DNA-PK [12](Cell-free assay)ATM [12](Cell-free assay)MLCK (Cell-free assay)ATR [12](Cell-free assay)
3 nM16 nM150 nM170 nM1.8 μM

化学数据

目录号A11161
作用机制Inhibitor (抑制剂)
M. Wt428.43
FormulaC23H24O8
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.19545-26-7
SynonymsSL-2052
SMILESCC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C

溶解度

In vitro (25°C)DMSO73 mg/mL (170.38 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+40% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.34 mL116.71 mL233.41 mL
0.5 mM4.67 mL23.34 mL46.68 mL
1 mM2.33 mL11.67 mL23.34 mL
5 mM0.47 mL2.33 mL4.67 mL

*The above data is based on the productmolecular weight 428.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.