生物活性
CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。
Targets
| Target | Value |
| HDAC1 | IC50: 1.7nM |
| HDAC3 | IC50: 1.8nM |
| HDAC10 | IC50: 2.8nM |
| HDAC2 | IC50: 5.0nM |
| HDAC11 | IC50: 5.4nM |
| PI3Kα | IC50: 19nM |
| HDAC6 | IC50: 27nM |
| PI3Kδ | IC50: 39nM |
| PI3Kβ | IC50: 54nM |
| HDAC8 | IC50: 191nM |
| PI3Kγ | IC50: 311nM |
| HDAC4 | IC50: 409nM |
| HDAC7 | IC50: 426nM |
| HDAC9 | IC50: 554nM |
| HDAC5 | IC50: 674nM |
化学数据
| 目录号 | A11153 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 508.6 |
| Formula | C23H24N8O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1339928-25-4 |
| Synonyms | CUDC907 |
| SMILES | CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO |
溶解度
| In vitro | DMSO | 87 mg/mL (171.07 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.66 mL | 98.31 mL | 196.62 mL |
| 0.5 mM | 3.93 mL | 19.66 mL | 39.32 mL |
| 1 mM | 1.97 mL | 9.83 mL | 19.66 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.93 mL |
*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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