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CUDC-907(Fimepinostat)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CUDC-907(Fimepinostat)图片
CAS NO:1339928-25-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CUDC907
产品介绍

生物活性

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂,作用于PI3Kα和HDAC1/2/3/10,IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。

Targets

TargetValue
HDAC1IC50: 1.7nM
HDAC3IC50: 1.8nM
HDAC10IC50: 2.8nM
HDAC2IC50: 5.0nM
HDAC11IC50: 5.4nM
PI3KαIC50: 19nM
HDAC6IC50: 27nM
PI3KδIC50: 39nM
PI3KβIC50: 54nM
HDAC8IC50: 191nM
PI3KγIC50: 311nM
HDAC4IC50: 409nM
HDAC7IC50: 426nM
HDAC9IC50: 554nM
HDAC5IC50: 674nM

化学数据

目录号A11153
作用机制Inhibitor (抑制剂)
M. Wt508.6
FormulaC23H24N8O4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1339928-25-4
SynonymsCUDC907
SMILESCN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO

溶解度

In vitroDMSO87 mg/mL (171.07 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.66 mL98.31 mL196.62 mL
0.5 mM3.93 mL19.66 mL39.32 mL
1 mM1.97 mL9.83 mL19.66 mL
5 mM0.39 mL1.97 mL3.93 mL

*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.