生物活性
CEP-18770 (Delanzomib)是一种新型口服活性蛋白酶体抑制剂，IC50为3.8 nM，具有良好的肿瘤选择性，可用于治疗对蛋白酶体抑制有反应的MM和其他恶性肿瘤。
靶点信息
| Chymotrypsin-like proteasome | | | | |
| 3.8 nM | | | | |
化学数据
| 目录号 | A11145 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 413.3 |
| Formula | C21H28BN3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 847499-27-8 |
| Synonyms | CEP18770 |
| SMILES | B([C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)O |
溶解度
| In vitro | DMSO | 73 mg/mL (176.63 mM) |
| Water | Insoluble |
| Ethanol | 73 mg/mL (176.63 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 24.2 mL | 120.98 mL | 241.95 mL |
| 0.5 mM | 4.84 mL | 24.2 mL | 48.39 mL |
| 1 mM | 2.42 mL | 12.1 mL | 24.2 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
*The above data is based on the productmolecular weight 413.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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