生物活性
TOK-001 (Galeterone)既是雄激素受体拮抗剂又是CYP17A1抑制剂。
靶点信息
| CYP17 | Androgen Receptor | | | |
| 300 nM | 384 nM | | | |
化学数据
| 目录号 | A11138 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 388.3 |
| Formula | C26H32N2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 851983-85-2 |
| Synonyms | VN/124-1 |
| SMILES | C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O |
溶解度
| In vitro (25°C) | DMSO | 21 mg/mL (54.04 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 36 mg/mL (92.65 mM) |
| In vivo | 0.5% hydroxyethyl cellulose | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.75 mL | 128.77 mL | 257.53 mL |
| 0.5 mM | 5.15 mL | 25.75 mL | 51.51 mL |
| 1 mM | 2.58 mL | 12.88 mL | 25.75 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.15 mL |
*The above data is based on the productmolecular weight 388.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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