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CH5424802
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CH5424802图片
CAS NO:1256580-46-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
CH-5424802
产品介绍

生物活性

CH5424802是一种有效的,选择性的,口服的ALK抑制剂,具有独特的化学支架,对具有ALK基因改变的癌症表现出优先的抗肿瘤活性。

Targets

TargetValue
ALK(F1174L)IC50: 1nM
ALKIC50: 1.9nM
ALK(R1275Q)IC50: 3.5nM
INSRIC50: 550nM
KDRIC50: 1.4μM
AblIC50: >5μM
EGFRIC50: >5μM
FGFR2IC50: >5μM
HER2IC50: >5μM
IGF-1RIC50: >5μM
JAK1IC50: >5μM
KitIC50: >5μM
MetIC50: >5μM
PDGFRβIC50: >5μM
SrcIC50: >5μM
Akt1IC50: >5μM
Akt2IC50: >5μM
Akt3IC50: >5μM
AuroraAIC50: >5μM
CDK1IC50: >5μM
CDK2IC50: >5μM
MEK1IC50: >5μM
PKAIC50: >5μM
PKCαIC50: >5μM
PKCβ1IC50: >5μM
PKCβ2IC50: >5μM
Raf-1IC50: >5μM

化学数据

目录号A11134
作用机制Inhibitor (抑制剂)
M. Wt482.6
FormulaC30H34N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1256580-46-7
SynonymsCH-5424802
SMILESCCC1=C(C=C2C(=C1)C(=O)C3=C(C2(C)C)NC4=C3C=CC(=C4)C#N)N5CCC(CC5)N6CCOCC6

溶解度

In vitroDMSOWarmed: 0.5 mg/mL (1.03 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.72 mL103.61 mL207.21 mL
0.5 mM4.14 mL20.72 mL41.44 mL
1 mM2.07 mL10.36 mL20.72 mL
5 mM0.41 mL2.07 mL4.14 mL

*The above data is based on the productmolecular weight 482.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.