生物活性
LY2109761是一种新型的I型和II型转化生长因子β受体双重抑制剂，对Smad2的磷酸化产生负面影响，作为抑制胰腺癌转移的治疗方法。
化学数据
| 目录号 | A11133 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 441.5 |
| Formula | C26H27N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 700874-71-1 |
| Synonyms | LY-2109761 |
| SMILES | C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6 |
溶解度
| In vitro (25°C) | DMSO | 2 mg/mL (4.52 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 0.5% CMC+0.25% Tween 80 (suspensions) | 15 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.65 mL | 113.25 mL | 226.5 mL |
| 0.5 mM | 4.53 mL | 22.65 mL | 45.3 mL |
| 1 mM | 2.27 mL | 11.33 mL | 22.65 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.53 mL |
*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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