生物活性
Dinaciclib (SCH 727965)是一种有效且选择性的细胞周期蛋白依赖性激酶（CDK）抑制剂，选择性抑制CDK1，CDK2，CDK5和CDK9，IC50值分别为3、1、1和4 nM。
靶点信息
| CDK2 (Cell-free assay) | CDK5 (Cell-free assay) | CDK1 (Cell-free assay) | CDK9 (Cell-free assay) | |
| 1 nM | 1 nM | 3 nM | 4 nM | |
化学数据
| 目录号 | A11129 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 396.5 |
| Formula | C21H28N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 779353-01-4 |
| Synonyms | SCH727965, SCH-727965 |
| SMILES | CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO |
溶解度
| In vitro (25°C) | DMSO | Warmed: 22 mg/mL (55.48 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 7 mg/mL (17.65 mM) |
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 9 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.22 mL | 126.1 mL | 252.21 mL |
| 0.5 mM | 5.04 mL | 25.22 mL | 50.44 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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