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Dinaciclib(SCH 727965)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dinaciclib(SCH 727965)图片
CAS NO:779353-01-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
SCH727965, SCH-727965
产品介绍

生物活性

Dinaciclib (SCH 727965)是一种有效且选择性的细胞周期蛋白依赖性激酶(CDK)抑制剂,选择性抑制CDK1,CDK2,CDK5和CDK9,IC50值分别为3、1、1和4 nM。

靶点信息

CDK2 (Cell-free assay)CDK5 (Cell-free assay)CDK1 (Cell-free assay)CDK9 (Cell-free assay)
1 nM1 nM3 nM4 nM

化学数据

目录号A11129
作用机制Inhibitor (抑制剂)
M. Wt396.5
FormulaC21H28N6O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.779353-01-4
SynonymsSCH727965, SCH-727965
SMILESCCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO

溶解度

In vitro (25°C)DMSOWarmed: 22 mg/mL (55.48 mM)
WaterInsoluble
EthanolWarmed: 7 mg/mL (17.65 mM)
In vivo2% DMSO+30% PEG 300+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.22 mL126.1 mL252.21 mL
0.5 mM5.04 mL25.22 mL50.44 mL
1 mM2.52 mL12.61 mL25.22 mL
5 mM0.5 mL2.52 mL5.04 mL

*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.