ML398 is potent D4 receptor Antagonist with IC50 = 130 nM and K i = 36 nM and shows no activity against the other dopamine receptors tested (>20 μM against D1, D2S, D2L, D3, and D5). Further in vivo studies showed that ML398 reversed cocaine-induced hyperlocomotion at 10 mg/kg. ML398 shows >100-fold selectivity for the other dopamine receptors. References: Berry CB, Locuson CW, Daniels JS, Lindsley CW, Hopkins CR. Discovery and characterization of ML398, a potent and selective chiral morpholine based antagonist of the dopamine 4 (D(4)) receptor. 2014 Apr 15 [updated 2015 Jan 16]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from .gov/books/NBK280047/ PubMed PMID: 25834901.

纯度：≥98%

CAS：1379510-21-0