生物活性
Plerixafor 8HCl (DB06809)是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12介导调节的趋化性， IC50分别为44 nM和5.7 nM。
靶点信息
| CXCL12-mediated chemotaxis (Cell-free assay) | CXCR4 (Cell-free assay) | | | |
| 5.7 nM | 44 nM | | | |
化学数据
| 目录号 | A10913 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 794.5 |
| Formula | C28H54N8.8HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 155148-31-5 |
| Synonyms | DB06809, AMD3100, Mozobil |
| SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl |
溶解度
| In vitro (25°C) | DMSO | Insoluble |
| Water | 91 mg/mL (114.54 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 12.59 mL | 62.93 mL | 125.87 mL |
| 0.5 mM | 2.52 mL | 12.59 mL | 25.17 mL |
| 1 mM | 1.26 mL | 6.29 mL | 12.59 mL |
| 5 mM | 0.25 mL | 1.26 mL | 2.52 mL |
*The above data is based on the productmolecular weight 794.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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