生物活性
Tenofovir (Viread)属于一类称为核苷逆转录酶抑制剂(NRTIs)的药物。它通过减少血液中的HIV含量起作用。
靶点信息
化学数据
目录号 | A10908 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 287.2 |
Formula | C9H14N5O4P |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 147127-20-6 |
SMILES | C[C@H](CN1C=NC2=C1N=CN=C2N)OCP(=O)(O)O |
溶解度
In vitro (25°C) | DMSO | Warmed: 4 mg/mL (13.92 mM) |
Water | 2 mg/mL (6.96 mM) |
Ethanol | Insoluble |
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 34.82 mL | 174.09 mL | 348.19 mL |
0.5 mM | 6.96 mL | 34.82 mL | 69.64 mL |
1 mM | 3.48 mL | 17.41 mL | 34.82 mL |
5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
*The above data is based on the productmolecular weight 287.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.