生物活性
SP600125是一种JNK抑制剂，对于JNK-1和JNK-2，IC50 = 40 nM，对于JNK-3，IC50 = 90 nM。
Targets
| Target | Value |
| JNK1 | IC50: 40nM |
| JNK2 | IC50: 40nM |
| AuroraA | IC50: 60nM |
| TrkA | IC50: 70nM |
| JNK3 | IC50: 90nM |
| FLT3 | IC50: 90nM |
| MKK4 | IC50: 0.4μM |
| MKK6 | IC50: 1.0μM |
| PKB | IC50: 1.0μM |
| MKK3 | IC50: 1.5μM |
| PKCα | IC50: 1.5μM |
| p56LCK | IC50: 4.3μM |
| MKK7 | IC50: 5.1μM |
| MEKK1 | IC50: >10μM |
| ERK2 | IC50: >10μM |
| p38β | IC50: >10μM |
| PKA | IC50: >10μM |
| PKC | IC50: >10μM |
| PKCθ | IC50: >10μM |
| Chk1 | IC50: >10μM |
| EGF | IC50: >10μM |
| IKK1 | IC50: >10μM |
| IKK2 | IC50: >10μM |
化学数据
| 目录号 | A10860 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 220.2 |
| Formula | C14H8N2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 129-56-6 |
| SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O |
溶解度
| In vitro (25°C) | DMSO | 43 mg/mL (195.25 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 45.41 mL | 227.07 mL | 454.13 mL |
| 0.5 mM | 9.08 mL | 45.41 mL | 90.83 mL |
| 1 mM | 4.54 mL | 22.71 mL | 45.41 mL |
| 5 mM | 0.91 mL | 4.54 mL | 9.08 mL |
*The above data is based on the productmolecular weight 220.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com