生物活性
SNS-032（BMS-387032）是细胞周期蛋白依赖性激酶（Cdks）2、7和9的高度选择性和有效抑制剂，具有体外生长抑制作用，并具有诱导恶性B细胞凋亡的能力。
Targets
| Target | Value |
| CDK9/CyclinT | IC50: 4nM |
| CDK2/CyclinA | IC50: 38nM |
| CDK2/CyclinE | IC50: 48nM |
| CDK7/CyclinH | IC50: 62nM |
| GSK-3α | IC50: 230nM |
| CDK5/p35 | IC50: 340nM |
| CDK1/CyclinB | IC50: 480nM |
| GSK-3β | IC50: 660nM |
| CDK4/CyclinD | IC50: 925nM |
| CDK6/CyclinD | IC50: >1μM |
化学数据
| 目录号 | A10850 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 380.5 |
| Formula | C17H24N4O2S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 345627-80-7 |
| Synonyms | SNS032, BMS-387032, BMS387032 |
| SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3 |
溶解度
| In vitro (25°C) | DMSO | 74 mg/mL (194.46 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.28 mL | 131.41 mL | 262.81 mL |
| 0.5 mM | 5.26 mL | 26.28 mL | 52.56 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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