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Rosiglitazone(BRL-49653)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rosiglitazone(BRL-49653)图片
CAS NO:122320-73-4
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
Avandia, BRL-49653
产品介绍

生物活性

Rosiglitazone (BRL-49653)是有效的降糖药,也是有效的噻唑烷二酮类胰岛素增敏剂,在大鼠,3T3-L1和人体脂肪细胞中IC50分别为12,4和9 nM。Rosiglitazone是PPAR-gamma的配体,对PPAR-alpha没有结合力。

靶点信息

PPAR (Cell-free assay)

化学数据

目录号A10807
作用机制Agonist (激动剂)
M. Wt357.4
FormulaC18H19N3O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.122320-73-4
SynonymsAvandia, BRL-49653
SMILESCN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3

溶解度

In vitro (25°C)DMSO65 mg/mL (181.85 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.98 mL139.9 mL279.8 mL
0.5 mM5.6 mL27.98 mL55.96 mL
1 mM2.8 mL13.99 mL27.98 mL
5 mM0.56 mL2.8 mL5.6 mL

*The above data is based on the productmolecular weight 357.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.