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Roflumilast
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Roflumilast图片
CAS NO:162401-32-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Daxas, Daliresp
产品介绍

生物活性

Roflumilast可作为PDE-4酶的选择性长效抑制剂,无细胞试验中IC50为0.2-4.3 nM。

Targets

TargetValue
PDE4B2IC50: 0.2nM
PDE4A1IC50: 0.7nM
PDE4B1IC50: 0.7nM
PDE4A4IC50: 0.9nM
PDE4C1IC50: 3nM
PDE4C2IC50: 4.3nM

化学数据

目录号A10804
作用机制Inhibitor (抑制剂)
M. Wt403.2
FormulaC17H14Cl2F2N2O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.162401-32-3
SynonymsDaxas, Daliresp
SMILESC1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F

溶解度

In vitro (25°C)DMSO70 mg/mL (173.6 mM)
WaterInsoluble
Ethanol13 mg/mL (32.24 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.8 mL124.01 mL248.02 mL
0.5 mM4.96 mL24.8 mL49.6 mL
1 mM2.48 mL12.4 mL24.8 mL
5 mM0.5 mL2.48 mL4.96 mL

*The above data is based on the productmolecular weight 403.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.