生物活性
Ritonavir是一种蛋白酶抑制剂，具有抗人类免疫缺陷病毒1型(hiv-1)的活性。蛋白酶抑制剂阻断hiv中被称为蛋白酶的部分，利托那韦抑制hiv病毒蛋白酶，这种蛋白酶防止gag-pol多蛋白的裂解，从而产生非感染性的未成熟病毒颗粒。
靶点信息
化学数据
| 目录号 | A10799 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 720.9 |
| Formula | C37H48N6O5S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 155213-67-5 |
| Synonyms | Norvir, Norvir Softgel |
| SMILES | CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O |
溶解度
| In vitro (25°C) | DMSO | 94 mg/mL (130.38 mM) |
| Water | Insoluble |
| Ethanol | 3 mg/mL (4.16 mM) |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 13.87 mL | 69.36 mL | 138.72 mL |
| 0.5 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 1 mM | 1.39 mL | 6.94 mL | 13.87 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.77 mL |
*The above data is based on the productmolecular weight 720.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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