生物活性
Rifabutin是一种主要用于治疗肺结核的杀菌抗生素。它的作用是基于阻断细菌的DNA依赖性RNA聚合酶。
化学数据
| 目录号 | A10790 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 847.0 |
| Formula | C46H62N4O11 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 72559-06-9 |
| Synonyms | Mycobutin |
| SMILES | C[C@H]1/C=C/C=C(\C(=O)NC2=C3C(=NC4(N3)CCN(CC4)CC(C)C)C5=C6C(=C(C(=C5C2=O)O)C)O[C@@](C6=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)/C |
溶解度
| In vitro | DMSO | 59 mg/mL (69.65 mM) |
| Water | Insoluble |
| Ethanol | 39 mg/mL (46.04 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 11.81 mL | 59.03 mL | 118.06 mL |
| 0.5 mM | 2.36 mL | 11.81 mL | 23.61 mL |
| 1 mM | 1.18 mL | 5.9 mL | 11.81 mL |
| 5 mM | 0.24 mL | 1.18 mL | 2.36 mL |
*The above data is based on the productmolecular weight 847.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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