A synthetic analog of glucose used in cell metabolism and cancer research
CAS： 33068-19-8
分子式：C6H12O8P?Na
分子量：266.1
纯度：98%
存储：Store at -20°C

Background:

2-deoxy-D-Glucose is a synthetic analog of glucose used in cell metabolism and cancer research.1 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.2 However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase.

Reference：

1. Kang, H.T., and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic Life Sciences 78(12), 1392-1399 (2006).

2. Urakami, K., Zangiacomi, V., Yamaguchi, K., et al. Impact of 2-deoxy-D-glucose on the target metabolite profile of a human endometrial cancer cell line Biomed.Res. 34(5), 221-229 (2013)