生物活性
Pemetrexed disodium (Alimta)是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT。
靶点信息
| TS (Cell-free assay) | DHFR (Cell-free assay) | GARFT (Cell-free assay) | | |
| 1.3 nM(Ki) | 7.2 nM(Ki) | 65 nM(Ki) | | |
化学数据
| 目录号 | A10707 |
| M. Wt | 471.4 |
| Formula | C20H19N5Na2O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 150399-23-8 |
| Synonyms | LY-231514, LY231514 |
| SMILES | C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+] |
溶解度
| In vitro (25°C) | DMSO | Insoluble |
| Water | 87 mg/mL (184.56 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.21 mL | 106.07 mL | 212.13 mL |
| 0.5 mM | 4.24 mL | 21.21 mL | 42.43 mL |
| 1 mM | 2.12 mL | 10.61 mL | 21.21 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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