生物活性
Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂，可特异性地耗尽HDAC1蛋白，而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。
靶点信息
化学数据
| 目录号 | A10698 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 248.3 |
| Formula | C15H20O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 20554-84-1 |
| SMILES | C/C/1=C/CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C |
溶解度
| In vitro (25°C) | DMSO | 49 mg/mL (197.32 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 49 mg/mL (197.32 mM) |
| In vivo | 2% DMSO+corn oil | 9 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 40.27 mL | 201.37 mL | 402.74 mL |
| 0.5 mM | 8.05 mL | 40.27 mL | 80.55 mL |
| 1 mM | 4.03 mL | 20.14 mL | 40.27 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.05 mL |
*The above data is based on the productmolecular weight 248.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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