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OSI-930
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OSI-930图片
CAS NO:728033-96-3
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
OSI930
产品介绍

生物活性

OSI-930是Kit,KDR,Flt,CSF-1R,c-Raf和Lck的有效抑制剂,IC50分别为80 nM,9 nM,8 nM,15 nM,41 nM和22 nM。

Targets

TargetValue
FLT1IC50: 8nM
KDRIC50: 9nM
CSF-1RIC50: 15nM
LCKIC50: 22nM
C-RafIC50: 41nM
KitIC50: 80nM
FLT3IC50: 1.303μM
PDGFRαIC50: 3.408μM
AblIC50: 4.738μM
PDGFRβIC50: 6.9μM
EGFRIC50: >10μM
AuroraAIC50: >10μM
AxlIC50: >10μM
CDK2/CyclinAIC50: >10μM
IKKβIC50: >10μM
MEK1IC50: >10μM
PDPK1IC50: >10μM
PKBβIC50: >10μM
Tie-2IC50: >10μM

化学数据

目录号A10679
作用机制Inhibitor (抑制剂)
M. Wt443.4
FormulaC22H16F3N3O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.728033-96-3
SynonymsOSI930
SMILESC1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F

溶解度

In vitro (25°C)DMSO85 mg/mL (191.68 mM)
WaterInsoluble
Ethanol3 mg/mL
In vivo30% PEG400+0.5% Tween80+5% propylene glycol4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.55 mL112.76 mL225.53 mL
0.5 mM4.51 mL22.55 mL45.11 mL
1 mM2.26 mL11.28 mL22.55 mL
5 mM0.45 mL2.26 mL4.51 mL

*The above data is based on the productmolecular weight 443.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.