生物活性
MC1568是HDAC抑制剂的成员,它通过修饰细胞周期的各种重要基因的基因表达(主要在G1期)来抑制II类组蛋白脱乙酰基酶,从而导致细胞凋亡导致乳腺癌细胞死亡。
靶点信息
HD1-A (Maize) (Cell-free assay) | HD1-B (Maize) (Cell-free assay) | | | |
100 nM | 3.4 μM | | | |
化学数据
目录号 | A10560 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 314.3 |
Formula | C17H15FN2O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 852475-26-4 |
Synonyms | MC-1568 |
SMILES | CN1C=C(C=C1/C=C/C(=O)NO)/C=C/C(=O)C2=CC(=CC=C2)F |
溶解度
In vitro (25°C) | DMSO | 12 mg/mL (38.18 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 0.5% CMC | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 31.82 mL | 159.08 mL | 318.17 mL |
0.5 mM | 6.36 mL | 31.82 mL | 63.63 mL |
1 mM | 3.18 mL | 15.91 mL | 31.82 mL |
5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
*The above data is based on the productmolecular weight 314.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.