您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Masitinib(AB1010)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Masitinib(AB1010)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Masitinib(AB1010)图片
CAS NO:790299-79-5
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AB1010, Masivet
产品介绍

生物活性

Masitinib (AB1010)是一种蛋白质酪氨酸激酶抑制剂。

Targets

TargetValue
KitIC50: 200nM
LynBIC50: 510nM
PDGFRαIC50: 540nM
PDGFRβIC50: 800nM
Abl1IC50: 1.20μM
c-FmsIC50: 1.48μM
SrcIC50: 1.87μM
HckIC50: 2.0μM
FLT3IC50: >10μM
VEGFR1IC50: >10μM
VEGFR2IC50: >10μM
EGFRIC50: >10μM
FGFR1IC50: >10μM
FGFR3IC50: >10μM
IGF-1RIC50: >10μM
c-MetIC50: >10μM
c-RetIC50: >10μM
JAK2IC50: >10μM
BTKIC50: >10μM
BmxIC50: >10μM
SykIC50: >10μM
FesIC50: >10μM
PKCαIC50: >10μM
Pim1IC50: >10μM
Akt1IC50: >10μM

化学数据

目录号A10558
作用机制Inhibitor (抑制剂)
M. Wt498.6
FormulaC28H30N6OS
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.790299-79-5
SynonymsAB1010, Masivet
SMILESCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

溶解度

In vitro (25°C)DMSO91 mg/mL (182.49 mM)
WaterInsoluble
Ethanol4 mg/mL
In vivo4% DMSO+30% PEG 300+5% Tween 80+ddH2O28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.06 mL100.28 mL200.56 mL
0.5 mM4.01 mL20.06 mL40.11 mL
1 mM2.01 mL10.03 mL20.06 mL
5 mM0.4 mL2.01 mL4.01 mL

*The above data is based on the productmolecular weight 498.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.