生物活性
LY-404039是一种用于科学研究的药物，用作代谢型谷氨酸受体II亚型mGluR2和mGluR3的选择性激动剂。它在动物研究中具有抗焦虑和抗精神病作用，但不会引起镇静作用。早期的人体试验使用LY-404，039前药形式LY-214，0023，也取得了令人鼓舞的结果。
靶点信息
| Rat neurons expressing native mGlu2/3 | Recombinant human mGlu3 | Recombinant human mGlu2 | | |
| 88 nM(Ki) | 92 nM(Ki) | 149 nM(Ki) | | |
化学数据
| 目录号 | A10544 |
| 作用机制 | Agonist (激动剂) |
| M. Wt | 235.2 |
| Formula | C7H9NO6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 635318-11-5 |
| Synonyms | LY-404039, LY-2140023 |
| SMILES | C1[C@]([C@@H]2[C@H]([C@@H]2S1(=O)=O)C(=O)O)(C(=O)O)N |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 42.52 mL | 212.59 mL | 425.17 mL |
| 0.5 mM | 8.5 mL | 42.52 mL | 85.03 mL |
| 1 mM | 4.25 mL | 21.26 mL | 42.52 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.5 mL |
*The above data is based on the productmolecular weight 235.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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