Background:

Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

Reference:
[1]. Actin-latrunculin A structure and function.Yarmola et al.J.Biol.Chem., 2000;275:28120
[2]. Latrunculin alters the actin-monomer subunit interface to prevent polymerization.Morton et al.Nat.Cell Biol., 2000;2:376
[3]. On the chemistry of latrunculins A and B. Blasberger et al. Liebigs.Ann.Chem., 1989;1989:1171