Cathepsin L inhibitor is a potent inhibitor of cathepsin L (IC50 = 0.85 nM).
CAS：167498-29-5
分子式：C26H26N2O5
分子量：446.5
纯度：98%
存储：Store at -20°C

Background:

Cathepsin L inhibitor is a potent inhibitor of cathepsin L (IC50 = 0.85 nM). It is selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively). It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. Cathepsin L inhibitor completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml., In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner.