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Inflachromene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Inflachromene图片
CAS NO:908568-01-4
规格:98%
分子量:377.4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.
CAS:908568-01-4
分子式:C21H19N3O4
分子量:377.4
纯度:98%
存储:Store at -20°C

Background:

Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.[1] It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage. Inflachromene also ameliorates inflammatory pathogenesis in a mouse model of sepsis.[2]


Reference:
[1]. Lee, S., Nam, Y., Koo, J.Y., et al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat. Chem. Biol. 10(12), 1055-1060 (2014).
[2]. Cho, W., Koo, J.Y., Park, Y., et al. Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents. J. Med. Chem. 60(1), 170-179 (2017).