生物活性
LBH589是异羟肟酸，用作非选择性HDAC抑制剂，HDAC1的IC5o为0.23 nM。
靶点信息
| HDAC (MOLT-4 cells) | HDAC (Reh cells) | | | |
| 5 nM | 20 nM | | | |
化学数据
| 目录号 | A10518 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 349.4 |
| Formula | C21H23N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 404950-80-7 |
| Synonyms | NVP-LBH589, LBH-589 |
| SMILES | CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO |
溶解度
| In vitro (25°C) | DMSO | 60 mg/mL (171.7 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 2% DMSO+48% PEG 300+2% Tween 80+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 28.62 mL | 143.1 mL | 286.2 mL |
| 0.5 mM | 5.72 mL | 28.62 mL | 57.24 mL |
| 1 mM | 2.86 mL | 14.31 mL | 28.62 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.72 mL |
*The above data is based on the productmolecular weight 349.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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