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KU-55933
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KU-55933图片
CAS NO:587871-26-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
KU55933
产品介绍

生物活性

KU-55933是ATM抑制剂,通过抑制细胞增殖,并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。

Targets

TargetValue
ATMIC50: 12.9nM
DNA-PKIC50: 2.5μM
mTORIC50: 9.3μM
PI3KIC50: 16.6μM
ATRIC50: >100μM
PI4KIC50: >100μM

化学数据

目录号A10506
作用机制Inhibitor (抑制剂)
M. Wt395.5
FormulaC21H17NO3S2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.587871-26-9
SynonymsKU55933
SMILESC1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

溶解度

In vitro (25°C)DMSO29 mg/mL (73.33 mM)
WaterInsoluble
EthanolInsoluble
In vivo5%DMSO+40%PEG300+5%Tween80+50%ddH2O3.75 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.28 mL126.42 mL252.84 mL
0.5 mM5.06 mL25.28 mL50.57 mL
1 mM2.53 mL12.64 mL25.28 mL
5 mM0.51 mL2.53 mL5.06 mL

*The above data is based on the productmolecular weight 395.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.