生物活性
KU-55933是ATM抑制剂,通过抑制细胞增殖,并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。
Targets
Target | Value |
ATM | IC50: 12.9nM |
DNA-PK | IC50: 2.5μM |
mTOR | IC50: 9.3μM |
PI3K | IC50: 16.6μM |
ATR | IC50: >100μM |
PI4K | IC50: >100μM |
化学数据
目录号 | A10506 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 395.5 |
Formula | C21H17NO3S2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 587871-26-9 |
Synonyms | KU55933 |
SMILES | C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4 |
溶解度
In vitro (25°C) | DMSO | 29 mg/mL (73.33 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 3.75 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 25.28 mL | 126.42 mL | 252.84 mL |
0.5 mM | 5.06 mL | 25.28 mL | 50.57 mL |
1 mM | 2.53 mL | 12.64 mL | 25.28 mL |
5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
*The above data is based on the productmolecular weight 395.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.