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KU-0063794
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KU-0063794图片
CAS NO:938440-64-3
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
KU0063794
产品介绍

生物活性

KU-0063794是哺乳动物雷帕霉素靶位的选择性抑制剂(分别为mTORC1和mTORC2,IC50 ~10 nM)。

靶点信息

mTORC1 (Cell-free assay)mTORC2 (Cell-free assay)
~10 nM~10 nM

化学数据

目录号A10505
作用机制Inhibitor (抑制剂)
M. Wt465.5
FormulaC25H31N5O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.938440-64-3
SynonymsKU0063794
SMILESC[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5

溶解度

In vitro (25°C)DMSO16 mg/mL (34.36 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.48 mL107.41 mL214.82 mL
0.5 mM4.3 mL21.48 mL42.96 mL
1 mM2.15 mL10.74 mL21.48 mL
5 mM0.43 mL2.15 mL4.3 mL

*The above data is based on the productmolecular weight 465.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.