生物活性
JNJ-38877605是一种ATP竞争性的c-Met抑制剂，从而抑制c-Met磷酸化并破坏c-Met信号转导途径。
化学数据
| 目录号 | A10493 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 377.4 |
| Formula | C19H13F2N7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 943540-75-8 |
| Synonyms | JNJ38877605 |
| SMILES | CN1C=C(C=N1)C2=NN3C(=NN=C3C(C4=CC5=C(C=C4)N=CC=C5)(F)F)C=C2 |
溶解度
| In vitro (25°C) | DMSO | 33 mg/mL (87.45 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.5 mL | 132.49 mL | 264.97 mL |
| 0.5 mM | 5.3 mL | 26.5 mL | 52.99 mL |
| 1 mM | 2.65 mL | 13.25 mL | 26.5 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
*The above data is based on the productmolecular weight 377.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com