生物活性
JNJ-26481585 (Quisinostat)是一种pan-HDAC抑制剂，对HDAC1具有显著的效力(IC(50)，0.16 nmol/L)。
化学数据
| 目录号 | A10492 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 394.5 |
| Formula | C21H26N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 875320-29-9 |
| Synonyms | JNJ26481585 |
| SMILES | CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.35 mL | 126.74 mL | 253.49 mL |
| 0.5 mM | 5.07 mL | 25.35 mL | 50.7 mL |
| 1 mM | 2.53 mL | 12.67 mL | 25.35 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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