生物活性
Irinotecan (CPT 11)是喜树碱家族的一种化合物，是参与细胞DNA复制和转录的拓扑异构酶1的抑制剂。
靶点信息
化学数据
| 目录号 | A10479 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 677.2 |
| Formula | C33H38N4O6.HCl.3H2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 136572-09-3 |
| Synonyms | CPT 11, Camptosar, Campto, Irinotecan |
| SMILES | CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl |
溶解度
| In vitro | DMSO | 92 mg/mL (135.86 mM) |
| Water | 1 mg/mL (1.47 mM) |
| Ethanol | 6 mg/mL (8.85 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 14.77 mL | 73.83 mL | 147.67 mL |
| 0.5 mM | 2.95 mL | 14.77 mL | 29.53 mL |
| 1 mM | 1.48 mL | 7.38 mL | 14.77 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.95 mL |
*The above data is based on the productmolecular weight 677.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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