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Indomethacin(Indocid,Indocin)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indomethacin(Indocid,Indocin)图片
CAS NO:53-86-1
包装与价格:
包装价格(元)
500mg电议
10mM * 1mL in DMSO电议

产品名称
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin
产品介绍

生物活性

Indomethacin (Indocid, Indocin)是一种非选择性COX1和COX2抑制剂,IC50分别为0.1 μg/mL和5 μg/mL。吲哚美辛(吲哚满,吲哚满)是一种非甾体抗炎药,通常用于减轻发热、疼痛、僵硬和肿胀。

靶点信息

COX1COX-2
0.28 μM14 μM

化学数据

目录号A10474
作用机制Inhibitor (抑制剂)
M. Wt357.79
FormulaC19H16ClNO4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.53-86-1
SynonymsIndomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin
SMILESCC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

溶解度

In vitro (25°C)DMSO63 mg/mL (176.08 mM)
WaterInsoluble
Ethanol21 mg/mL (58.69 mM)
In vivo5% DMSO+30% PEG 300+5% Tween 80+ddH2O1 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.95 mL139.75 mL279.49 mL
0.5 mM5.59 mL27.95 mL55.9 mL
1 mM2.79 mL13.97 mL27.95 mL
5 mM0.56 mL2.79 mL5.59 mL

*The above data is based on the productmolecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.