| CAS NO: | 2438-32-6 |
| 规格: | 98% |
| 分子量: | 390.9 |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
Background:
Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro. It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM. Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM. In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg. Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.
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