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Thyroid Hormone Receptor Antagonist(1-850)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thyroid Hormone Receptor Antagonist(1-850)图片
CAS NO:251310-57-3
规格:98%
分子量:463.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Thyroid hormone receptor antagonist
CAS:251310-57-3
分子式:C21H20F3N5O4
分子量:463.4
纯度:98%
存储:Store at -20°C

Background:

Target: thyroid hormone receptor


IC50: 1.5 μM


Thyroid hormone receptor antagonist (1-850) was screened from a library of more than 250000 compounds as the antagonist of thyroid hormone receptor with the highest affinity. Thyroid Hormone Receptor Antagonist, 1-850 is a cell-permeable hydrazinyl-carboxamide compound which functions as a selective and high-affinity thyroid receptor antagonist with the IC50 value of 1.5 μM in Hela cells [1].


The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone, which plays a critical role in the regulation of metabolism and heart rate and the development of organisms. Thyroid hormone receptor antagonist (1-850) could competitively block T3 (L-triiodothyronine) binding to both TRα and TRβ, and suppress T3 mediated interaction of TRα with nuclear receptor coactivator (NRC) as well as prevent the stimulation of gene expression [1].


In Vitro: no data available.


In Vivo: no data available.


Clinical trial: no data available.


Reference:
[1] Schapira M, Raaka B M, Das S, et al.  Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking[J]. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(12): 7354-7359.