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Tenuazonic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenuazonic Acid图片
CAS NO:610-88-8
规格:98%
分子量:260.8
包装与价格:
包装价格(元)
1mg电议
10mg电议
25mg电议

产品介绍
One of the major Alternaria mycotoxins
CAS:610-88-8
分子式:C10H15NO3 ? Cu
分子量:260.8
纯度:98%
存储:Store at -20°C

Background:

Tenuazonic acid is one of the major Alternaria mycotoxins commonly found as a natural contaminant in food (LD50 = 548 μg/egg in the chicken embryo toxicity assay).1 Tenuazonic acid contamination has been linked to esophageal cancer in human populations at risk of high exposure. Mice fed 100 mg/kg/day tenuazonic acid orally for 10 months developed precancerous lesions on the esophageal mucosa.2 Microscopic analysis of mucosal epithelial cells from these tenuazonic acid-treated animals reveal pyknosis and marked pleomorphisms in the nuclei, chromatin granulation and increased chromatin mass, irregularities in nuclear contours, and vacuolization in nucleoplasms.2


Reference


?1. Griffin, G.F., and Chu, F.S. Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay Applied and Environmental Microbiology 46(6), 1420-1422 (1983).
2. Yekeler, H., Bitmis, K., Oz?elik, N., et al. Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy Toxicologic Pathology 29, 492-497 (2001).