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Tiodazosin(BL-5111)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tiodazosin(BL-5111)图片
CAS NO:66969-81-1
规格:98%
分子量:431.47
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tiodazosin是一种有效且有竞争性的突触后α肾上腺素能受体(alphaadrenergicreceptor)拮抗剂。
CAS:66969-81-1
分子式:C18H21N7O4S
分子量:431.47
纯度:98%
存储:Store at -20°C

Background:

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.


Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].



[1]. Cohen ML, et al. In vitro comparison of the pre- and postsynaptic alpha adrenergic receptor blocking properties of prazosin and tiodazosin (BL5111).