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GSK1904529A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK1904529A图片
CAS NO:1089283-49-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
GSK-1904529A
产品介绍

生物活性

GSK1904529A分别用27和25 nmol/L的IC(50)s选择性抑制IGF-IR和IR。

Targets

TargetValue
Insulin ReceptorIC50: 25nM
IGF-1RIC50: 27nM
B-Raf(V600E)IC50: >2μM
SykIC50: 3.2μM
VEGFR2IC50: 3.2μM
IKK3IC50: 3.2μM
AuroraBIC50: 4μM
FynIC50: 6.3μM
RSK1IC50: 6.3μM
LCKIC50: 8μM
AuroraAIC50: >8μM
p38αIC50: 10μM
PKCεIC50: 10μM
PKCθIC50: >10μM
ActRIIBIC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
ALK5IC50: >10μM
CaMKK2IC50: >10μM
CDK2/CyclinAIC50: >10μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
JNK1IC50: >10μM
JNK2IC50: >10μM
JNK3IC50: >10μM
p70S6KIC50: >10μM
PAK1IC50: >10μM
PCTAIRE1IC50: >10μM
PDK-1IC50: >10μM
PI3KαIC50: >10μM
PI3KβIC50: >10μM
PI3KδIC50: >10μM
PI3KγIC50: >10μM
ROCK1IC50: >10μM
SIK2IC50: >10μM
Src1IC50: >10μM
YAK3IC50: >10μM
IKK1IC50: 13μM
IKK2IC50: 13μM
JAK3IC50: 13μM
JAK2IC50: >16μM
ZAP70IC50: >20μM
ASK1IC50: >25μM
ErbB4IC50: >25μM
GSK-3βIC50: >25μM
ITKIC50: >25μM
MAPKAPK2IC50: >25μM

化学数据

目录号A10440
作用机制Inhibitor (抑制剂)
M. Wt852
FormulaC44H47F2N9O5S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1089283-49-7
SynonymsGSK-1904529A
SMILESCCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F

溶解度

In vitroDMSO120 mg/mL (140.85 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM11.74 mL58.69 mL117.37 mL
0.5 mM2.35 mL11.74 mL23.47 mL
1 mM1.17 mL5.87 mL11.74 mL
5 mM0.23 mL1.17 mL2.35 mL

*The above data is based on the productmolecular weight 852. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.