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Gemcitabine HCl(Gemzar)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gemcitabine HCl(Gemzar)图片
CAS NO:122111-03-9
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍

生物活性

Gemcitabine HCl (Gemzar)是一种DNA synthesis抑制剂,作用于PANC1,MIAPaCa2,BxPC3和Capan2细胞,通过在癌细胞dna复制过程中取代核酸的一个组成部分,防止肿瘤生长。

靶点信息

DNA synthesis (Capan2 cells)DNA synthesis (BxPC3 cells)DNA synthesis (MIAPaCa2 cells)DNA synthesis (PANC1 cells)
12 nM18 nM40 nM50 nM

化学数据

目录号A10423
作用机制Inhibitor (抑制剂)
M. Wt299.7
FormulaC9H11F2N3O4.HCI
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.122111-03-9
SMILESC1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl

溶解度

In vitro (25°C)DMSOInsoluble
Water18 mg/mL (60.06 mM)
EthanolInsoluble
In vivoSaline18 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM33.37 mL166.83 mL333.67 mL
0.5 mM6.67 mL33.37 mL66.73 mL
1 mM3.34 mL16.68 mL33.37 mL
5 mM0.67 mL3.34 mL6.67 mL

*The above data is based on the productmolecular weight 299.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.