生物活性
Gemcitabine HCl (Gemzar)是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，通过在癌细胞dna复制过程中取代核酸的一个组成部分，防止肿瘤生长。
靶点信息
| DNA synthesis (Capan2 cells) | DNA synthesis (BxPC3 cells) | DNA synthesis (MIAPaCa2 cells) | DNA synthesis (PANC1 cells) | |
| 12 nM | 18 nM | 40 nM | 50 nM | |
化学数据
| 目录号 | A10423 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 299.7 |
| Formula | C9H11F2N3O4.HCI |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 122111-03-9 |
| SMILES | C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl |
溶解度
| In vitro (25°C) | DMSO | Insoluble |
| Water | 18 mg/mL (60.06 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 18 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 33.37 mL | 166.83 mL | 333.67 mL |
| 0.5 mM | 6.67 mL | 33.37 mL | 66.73 mL |
| 1 mM | 3.34 mL | 16.68 mL | 33.37 mL |
| 5 mM | 0.67 mL | 3.34 mL | 6.67 mL |
*The above data is based on the productmolecular weight 299.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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