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S-1 Methanandamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-1 Methanandamide图片
CAS NO:157182-50-8
规格:98%
分子量:361.6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
CB1 receptor ligand
CAS:157182-50-8
分子式:C23H39NO2
分子量:361.6
纯度:98%
存储:Store at -20°C

Background:

S-1 methanandamide is a CB1 receptor ligand.


The cannabinoid receptor type 1 (CB1), is a G protein-coupled cannabinoid receptor located mainly in the central and peripheral nervous system. CB1 is also expressed in several cells relating to metabolism, such as muscle cells, fat cells, liver cells, and the digestive tract. The CB1 receptor has been involved in the maintenance of homeostasis in health and disease, preventing the development of excessive neuronal activity, reducing pain and other inflammatory symptoms. Enhanced receptor expression has been identified in human hepatocellular carcinoma tumor samples and human prostate cancer cells [2].


S-1 methanandamide was a less potent than the C-1 (R) methyl isomer when binding with CB1 receptor. S-1 methanandamide inhibited electrically evoked contractions in isolated mouse vasa deferentia with an IC50 value of 230 nM. The binding affinity of S-1 methanandamide for CB1 receptors was less than that of AEA, with a Ki of 175 nM for the displacement of radiolabeled CP 55,940 [1].


参考文献:
[1] Abadji V, Lin S, Taha G, et al.  (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[J]. Journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] Howlett A C.  Cannabinoid receptor signaling[M]//Cannabinoids. Springer Berlin Heidelberg, 2005: 53-79.