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CPI-444(V81444)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CPI-444(V81444)图片
CAS NO:1202402-40-1
规格:98%
分子量:407.43
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CPI-444是一种有效的选择性A2A受体(A2AR)抑制剂,诱导抗肿瘤反应。
CAS:1202402-40-1
分子式:C20H21N7O3
分子量:407.43
纯度:98%
存储:Store at -20°C

Background:

CPI-444 is a potent and selective inhibitor of A2A receptor (A2AR) induces antitumor responses.


CPI-444 is a potent, oral, selective A2AR antagonist. CD8+ T cell depletion abrogates the efficacy of CPI-444 treatment as a single agent as well as in combination with anti-PD-L1, demonstrating a role for CD8+ T cells in mediating primary and secondary immune responses. Anti-tumor efficacy of CPI-444±anti-PD-L1 is associated with increased CD8+ cell infiltration and activation in MC38 tumor tissues, and a corresponding rise in PD-1 expression on CD8+ T cells in the spleen. Additionally, levels of immune checkpoints are modulated by treatment with CPI-444, including GITR, OX40, and LAG3 on tumor infiltrating lymphocytes and circulating T cells, suggesting a broad role for adenosine mediated immunosuppression[1].


Daily treatment of the syngeneic mouse model MC38 with CPI-444 (1, 10, 100 mg/kg) leads to dose-dependent inhibition of tumor growth, leading to tumor elimination in