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BYK 204165
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BYK 204165图片
CAS NO:1104546-89-5
规格:98%
分子量:252.27
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
PARP-1 inhibitor,potent and selective
CAS:1104546-89-5
分子式:C15H12N2O2
分子量:252.27
纯度:98%
存储:Store at -20°C

Background:

BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor with pIC50 values of 5.38 and 7.35 for PARP-2 and PARP-1 respectively [1].
PARP1 is a nuclear enzyme activated by strand breaks in DNA and involved in the regulation of various cell processes such as DNA repair, apoptosis, organ dysfunction or necrosis [1].
BYK 204165 (PARP inhibitor XIV) is a cell-permeable isoquinolinedione compound that potently and selectively inhibits PARP1. BYK 204165’s potency is similar or higher than most current standard PARP-1 inhibitors (just slightly lower than PJ34), and it is 100-fold selective for PARP-1 over PARP-2 [1].
BYK 204165 was not tested in vivo because of BYK its poor water solubility.
参考文献:
[1]. Eltze T, Boer R, Wagner T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol, 2008, 74(6): 1587-98.