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AUY922(NVP-AUY922)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AUY922(NVP-AUY922)图片
CAS NO:747412-49-3
规格:98%
分子量:465.5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议

产品介绍
Potent Hsp90 inhibitor
CAS:747412-49-3
分子式:C26H31N3O5
分子量:465.5
纯度:98%
存储:Store at -20°C

Background:

AUY922 (NVP-AUY922) is a potent, novel synthetic resorcinylic isoxazole amide inhibitor of heat shock protein 90 (HSP90).[1]It is a small molecular with the formula of C26H31N3O5and molecular weight of 465.5. It has a much higher af?nity for Hsp90 and can be ound to the ATP binding site of Hsp90 at the N-terminal domain.[2]Heat shock protein 90 (HSP90) is a molecular chaperone essential for the stability of key regulators of cell growth and survival. NVP-AUY922 potently inhibits the proliferation of gastric cancer cell lines with with GI50 values of approximately 2 to 40 nmol/L and significantly induces the degradation of growth factor receptors and other client proteins.[3]


参考文献:


[1]Suzanne A. E, Andy M, Florence I. R, et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68. 2850-2860.


[2] Tsuyoshi U, Kazunori T, Shinichi T, Midori A, Munenori T, et al. Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer. Lung Cancer. 2012, 76. 26-31.


[3] Kyung-Hun L, Ju-Hee L, Sae-Won H, Seock-Ah I, et al. Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins. Cancer Sci. 2011, 102. 1388–1395.