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GDC-0879
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GDC-0879图片
CAS NO:905281-76-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
GDC0879
产品介绍

生物活性

GDC-0879是B-Raf激酶的特异性抑制剂,靶向B-Raf (V600E) (IC50: 0.13 nM)。

靶点信息

B-Raf (A375, Colo205 cells)
0.13 nM

化学数据

目录号A10420
作用机制Inhibitor (抑制剂)
M. Wt334.4
FormulaC19H18N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.905281-76-7
SynonymsGDC0879
SMILESC1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

溶解度

In vitro (25°C)DMSOWarmed: 65 mg/mL (194.39 mM)
WaterInsoluble
Ethanol5 mg/mL (14.95 mM)
In vivo0.5% methylcellulose+0.2% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM29.9 mL149.52 mL299.04 mL
0.5 mM5.98 mL29.9 mL59.81 mL
1 mM2.99 mL14.95 mL29.9 mL
5 mM0.6 mL2.99 mL5.98 mL

*The above data is based on the productmolecular weight 334.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.