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Dasatinib(BMS-354825)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dasatinib(BMS-354825)图片
CAS NO:302962-49-8
规格:98%
分子量:488.01
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Src and BCR-Abl inhibitor
CAS:302962-49-8
分子式:C22H26ClN7O2S
分子量:488.01
纯度:98%
存储:Store at -20°C

Background:

Dasatinib is a small-molecule inhibitor of both the Src and Bcr-Abl tyrosine kinases with IC50?values of 0.5 nM and 1 nM. ?The oncogenic tyrosine kinase Bcr-Abl, plays a critical role in the pathogenesis of CML?(chronic myelogenous leukemia). In most CML patients, the kinase domain of Bcr-Abl have mutations that interfere with binding to the first Abl kinase inhibitor, but Dasatinib bind more efficiently to these Abl kinase mutations and thus more effective than imatinib in inhibiting the proliferation cells with wild-type Bcr-Abl or Bcr-Abl mutants.


参考文献
1. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. S Nam, D Kim, JQ Cheng, S Zhang, JH Lee, R Buettner. Cancer Research. 2005
2. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. L Song, M Morris, T Bagui, FY Lee, R Jove, EB Haura . Cancer Research. 2006