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AICAR phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AICAR phosphate图片
CAS NO:681006-28-0
规格:98%
分子量:356.23
包装与价格:
包装价格(元)
50mg电议
200mg电议
1g电议

产品介绍
AMPK activator
CAS:681006-28-0
分子式:C9H17N4O9P
分子量:356.23
纯度:98%
存储:Store at -20°C

Background:

AICAR phosphate (Acadesine)is an activator of AMPK [1].


AICAR phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the EC50 value is 380±60μM on the viability assay of B-CLL cells. In addition, AICAR phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in B-CLL cells. Furthermore, AICAR phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate AMPK. Apart from these, AICAR phosphate (2-4 mM) has shown to only slightly affects the viability of T cells from B-CLL patients, AICAR phosphate (0.5 mM) has been noted to remarkedly reduces viability of B cells but not T cells [1].


参考文献:
[1] Campàs C1, Lopez JM, Santidrián AF, Barragán M, Bellosillo B, Colomer D, Gil J. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003 May 1;101(9):3674-80. Epub 2003 Jan 9.