生物活性
FTY720 (Fingolimod)是ISP-1(肉豆蔻酸)的衍生物,ISP-1是中国草药Iscaria sinclarii的真菌代谢物,也是鞘氨醇的结构类似物。
靶点信息
S1P receptor (K562, NK cells ) | | | | |
0.033 nM | | | | |
化学数据
目录号 | A10408 |
作用机制 | Antagonist (拮抗剂) |
M. Wt | 343.9 |
Formula | C19H33NO2.HCl |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 162359-56-0 |
Synonyms | Gilenia |
SMILES | CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl |
溶解度
In vitro (25°C) | DMSO | 64 mg/mL (186.09 mM) |
Water | 64 mg/mL (186.09 mM) |
Ethanol | 64 mg/mL (186.09 mM) |
In vivo | Saline | 19 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 29.08 mL | 145.39 mL | 290.78 mL |
0.5 mM | 5.82 mL | 29.08 mL | 58.16 mL |
1 mM | 2.91 mL | 14.54 mL | 29.08 mL |
5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
*The above data is based on the productmolecular weight 343.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.