生物活性
Flucytosine是一种抗真菌药，用于治疗严重念珠菌和隐球菌感染。它进入真菌后转化为氟尿嘧啶，抑制DNA和RNA合成。
靶点信息
化学数据
| 目录号 | A10394 |
| M. Wt | 129.1 |
| Formula | C4H4FN3O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 2022-85-7 |
| Synonyms | 5-fluorocytosine, Ancotil |
| SMILES | C1=NC(=O)NC(=C1F)N |
溶解度
| In vitro (25°C) | DMSO | 7 mg/mL (54.22 mM) |
| Water | 4 mg/mL (30.98 mM) |
| Ethanol | Insoluble |
| In vivo | 0.5% methylcellulose+0.2% Tween 80 | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 77.46 mL | 387.3 mL | 774.59 mL |
| 0.5 mM | 15.49 mL | 77.46 mL | 154.92 mL |
| 1 mM | 7.75 mL | 38.73 mL | 77.46 mL |
| 5 mM | 1.55 mL | 7.75 mL | 15.49 mL |
*The above data is based on the productmolecular weight 129.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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